By Mark Gonzales

Associated Press

CHICAGO (AP) — Max Kepler homered twice, rookie Joe Ryan struck out a season-high 11, and the Minnesota Twins held on to beat the Chicago Cubs 5-4 Wednesday night.

Kepler staked the Twins to a 2-0 lead with a homer in the first inning and hit a tiebreaking drive in the fourth for his 11th multihomer game, his second time this season.

The Cubs and Twins are both 67-85, nearing the end of disappointing season. Chicago lost for the ninth time in 11 games.

Ryan (2-1), a U.S. Olympian acquired from the Tampa Bay on July 22 with minor league pitcher Drew Strotman for Nelson Cruz, limited the Cubs to three hits in five innings in his fourth major league appearance. The 25-year-old right-hander became the first pitcher in Washington Senators//Twins history with 11 strikeouts in five innings or fewer.

Ryan allowed a two-run single to Nico Hoerner in the second before retiring 10 of his final 11 batters.

Chicago’s Frank Schwindel extended his career-best hitting streak to 11 games with a single in the third.

Ryan struck out the next seven batters, including the last five on called third strikes.

Since losing to the Cubs 3-0 in his major league debut on Sept. 1, Ryan has allowed three runs while striking out 20 in 17 innings. He has a 2.45 ERA.

Cubs starter Kyle Hendricks (14-7) didn’t walk a batter for the ninth time in 31 starts. However, the two homers by Kepler increased Hendricks’ home runs allowed to a career-high 31 this season.

Nick Gordon hit a double in the ninth and scored on Andrelton Simmons’ sacrifice fly. Gordon is 6 for 15 in his last four games.

That run loomed large because the Cubs cut the deficit to one on Ian Happ’s single and Willson Contreras’ groundout. Closer Alex Colomé struck out Trayce Thompson with runners at second and third for his 15th save in 22 chances.

The Cubs struck out 18 times, tying their season high against Pittsburgh on Sept. 2.

Minnesota won its fourth consecutive game at Wrigley dating to Sept. 19 last year.

The Cubs finished interleague play 6-14, their first sub-.500 record since they went 9-11 in 2014.

TRAINER’S ROOM

Twins CF Bryon Buxton (foot) didn’t start after getting hit by a pitch in the ninth inning of Tuesday’s game. Buxton appeared as a pinch hitter in the seventh and legged out a double. 2B Jorge Polanco (illness) also didn’t start but hit a pinch-hit double in the ninth.

Cubs RF Jason Heyward (concussion) is doubtful to return this season, manager David Ross said. Heyward wants to return and will continue to undergo tests. Heyward was kneed in the head on a play at second against San Francisco on Sept. 11. … C Robinson Chirinos hurt his left side on a checked swing in the seventh and left the game.